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Invitrogen
NFRKB Polyclonal Antibody
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Product Details
PA5-99665
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NFRKB(Accession Q6P4R8), corresponding to amino acid residues Q463-S513.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NFRKB.
Target Information
NFRKB (nuclear factor related to kappa-B-binding protein) was first identified as a factor that could bind a variant NF-kappa B site in the interleukin-2 receptor alpha (IL-2R alpha) gene. NFRKB appears to be a transcription factor central to immune cell development. Evidence of this comes from the identification of NFRKB as an amplified gene in several cases of acute myeloid leukemia. Additionally, in another clinical case, a partial deletion of the chromosomal region that includes NFRKB is shown to be associated with combined cellular immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-binding protein R kappa B; DNA-binding protein R kappa-B; INO80 complex subunit G; Nuclear factor related to kappa-B-binding protein
Gene Aliases: INO80G; NFRKB
UniProt ID: (Human) Q6P4R8
Entrez Gene ID: (Human) 4798, (Rat) 315523
telomere maintenance
regulation of DNA replication
DNA repair
regulation of DNA repair
DNA recombination
chromatin remodeling
cellular response to DNA damage stimulus
positive regulation of macromolecule metabolic process
regulation of chromosome organization
positive regulation of DNA repair
positive regulation of transcription, DNA-templated
positive regulation of nucleobase-containing compound metabolic process
regulation of embryonic development
regulation of DNA metabolic process
regulation of cell cycle
regulation of DNA strand elongation
positive regulation of telomere maintenance in response to DNA damage
biological_process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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