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Invitrogen
NGAL Polyclonal Antibody
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Product Details
PA5-115502
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LCN2(Accession P80188), corresponding to amino acid residues Q40-L90.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total LCN2.
Target Information
NGAL (Neutrophil gelatinase-associated lipocalin, lipocalin 2, siderocalin and neutrophil lipocalin) is a 25 kDa glycosylated single chain monomer and member of the lipocalin family of proteins that bind and transport small lipophilic molecules. NGAL is released by activated neutrophils, can form dimers and small amounts of higher oligomers, and complexes with matrix metalloproteinase 9 (MMP-9, gelatinase B). Low level expression of NGAL in a variety of epithelia may be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increased by ischemic or nephrotoxic kidney injury.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Alpha-2-microglobulin-related protein; Alpha-2U globulin-related protein; HGNC:6526; LCN2; lipocalin 2 (oncogene 24p3); Lipocalin 24p3; Lipocalin-2; Lipocalin2; migration-stimulating factor inhibitor; Neutrophil gelatinase-associated lipocalin; neutrophil lipocalin; NGAL; Oncogene 24p3; OTTHUMP00000022240; p25; RP23-161B9.11; secreted inducible protein 24; Siderocalin; Siderocalin LCN2; SV-40-induced 24P3 protein; unnamed protein product; uterocalin
Gene Aliases: 24p3; AW212229; HNL; LCN2; MSFI; NGAL; p25; Sip24
UniProt ID: (Human) P80188, (Mouse) P11672, (Rat) P30152
Entrez Gene ID: (Human) 3934, (Mouse) 16819, (Rat) 170496
immune system process
ion transport
iron ion transport
apoptotic process
acute-phase response
response to oxidative stress
short-term memory
long-term memory
response to xenobiotic stimulus
response to virus
response to bacterium
response to herbicide
response to toxic substance
response to blue light
response to fructose
response to iron(II) ion
response to mycotoxin
positive regulation of endothelial cell migration
positive regulation of gene expression
siderophore transport
positive regulation of cell projection organization
response to nutrient levels
cellular response to nutrient levels
response to lipopolysaccharide
cellular response to increased oxygen levels
defense response to bacterium
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
innate immune response
cellular response to hydrogen peroxide
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to hypoxia
cellular response to X-ray
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of hippocampal neuron apoptotic process
negative regulation of hippocampal neuron apoptotic process
positive regulation of cold-induced thermogenesis
positive regulation of reactive oxygen species biosynthetic process
response to kainic acid
positive regulation of iron ion import across plasma membrane
cellular response to beta-amyloid
positive regulation of endothelial tube morphogenesis
cellular response to nerve growth factor stimulus
positive regulation of reactive oxygen species metabolic process
transport
response to drug
iron ion homeostasis
protein homotrimerization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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