Invitrogen

NGF Receptor Polyclonal Antibody

View all (102) NGFR (CD271) antibodies

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NGF Receptor Polyclonal Antibody

Product Details

PA5-96054

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 301-400 of human p75NTR/NGFR (NP_0024981)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

4.38 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807856

Product Specific Information

Positive Samples: PC-3, SW480, PC-12, A375, A673, ES-2, MCF7, Mouse heart, Mouse brain; Cellular Location: Membrane, Single-pass type I membrane protein

Immunogen sequence: LHSDSGISVD SQSLHDQQPH TQTASGQALK GDGGLYSSLP PAKREEVEKL LNGSAGDTWR HLAGELGYQP EHIDSFTHEA CPVRALLASW ATQDSATLDA

Target Information

Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; p-75; p75 ICD; p75 neurotrophin receptor; p75 ntr; TNFR superfamily, member 16; TNR16; Tumor necrosis factor receptor superfamily member 16

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Gene Aliases: CD271; Gp80-LNGFR; LNGFR; NGFR; p75; p75(NTR); p75NGFR; p75NTR; RNNGFRR; TNFRSF16

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UniProt ID: (Human) P08138, (Rat) P07174, (Mouse) Q9Z0W1

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Entrez Gene ID: (Human) 4804, (Rat) 24596, (Mouse) 18053

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Function(s)
beta-amyloid binding signal transducer activity receptor activity transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity neurotrophin TRKA receptor binding protein binding Rab GTPase binding ubiquitin protein ligase binding nerve growth factor binding preprotein binding death receptor activity neurotrophin binding transmembrane signal receptor
Process(es)
intracellular protein transport activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response immune response axon guidance response to wounding negative regulation of neuron projection development sensory perception of pain membrane protein intracellular domain proteolysis positive regulation of myelination positive regulation of synaptic transmission, cholinergic response to lipopolysaccharide circadian regulation of gene expression tumor necrosis factor-mediated signaling pathway cellular response to oxidative stress positive regulation of Rho protein signal transduction skeletal muscle cell differentiation regulation of cell proliferation glucose homeostasis regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process neurotrophin TRK receptor signaling pathway negative regulation of axonogenesis positive regulation of axonogenesis positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization positive regulation of synaptic transmission, glutamatergic apoptotic signaling pathway positive regulation of neuron death regulation of reactive oxygen species metabolic process regulation of glucose import in response to insulin stimulus apoptotic process signal transduction central nervous system development regulation of gene expression positive regulation of cell death programmed cell death detection of temperature stimulus nerve development hair follicle morphogenesis negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of odontogenesis of dentin-containing tooth skin development positive regulation of fibroblast proliferation negative regulation of hair follicle development negative regulation of cell death positive regulation of apoptotic signaling pathway multicellular organism development nervous system development cell differentiation rhythmic process
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