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Alomone Labs, LTD

NGF/proNGF Neutralizing Monoclonal Antibody (HAL06)

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NGF/proNGF Neutralizing Monoclonal Antibody (HAL06)

Product Details

ALM-006-250UG

Applications
Tested Dilution
Publications

ELISA (ELISA)

2 µg/mL
-

Neutralization (Neu)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

HAL06

Immunogen

Highly purified 2.5S mouse NGF, Secreted
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

250 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 50 µL or 0.25 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3. proNGF is abundant in central nervous system tissues whereas mature NGF is undetectable, suggesting that proNGF may have a function distinct from its role as a precursor. Studies suggest that proNGF has apoptotic activity which contrast with other data demonstrating that proNGF has neurotrophic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Beta-nerve growth factor; Beta-NGF; Nerve growth factor; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta subunit; NGFB; pro-nerve growth factor long; proNGF; unnamed protein product

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Gene Aliases: Beta-NGF; HSAN5; NGF; NGFB

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UniProt ID: (Human) P01138, (Mouse) P01139, (Rat) P25427

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Entrez Gene ID: (Human) 4803, (Mouse) 18049, (Rat) 310738

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Function(s)
enzyme inhibitor activity receptor binding nerve growth factor receptor binding protein binding growth factor activity metalloendopeptidase inhibitor activity lipid binding cysteine-type endopeptidase activator activity involved in apoptotic process transmembrane receptor protein tyrosine kinase activator activity peptidase inhibitor activity death receptor agonist activity receptor signaling protein activity molecular_function neurotrophic factor
Process(es)
signal transduction transmembrane receptor protein tyrosine kinase signaling pathway peripheral nervous system development circadian rhythm negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression positive regulation of neuron projection development positive regulation of neuron maturation sensory perception of pain nerve development neuron projection development positive regulation of protein ubiquitination nerve growth factor signaling pathway negative regulation of neuron apoptotic process regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of axon extension positive regulation of Ras protein signal transduction regulation of neurotransmitter secretion neurotrophin TRK receptor signaling pathway positive regulation of collateral sprouting axon extension neuron projection morphogenesis modulation of synaptic transmission regulation of release of sequestered calcium ion into cytosol neuron apoptotic process positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade extrinsic apoptotic signaling pathway in absence of ligand cell-cell signaling memory positive regulation of cell proliferation adult locomotory behavior negative regulation of peptidase activity negative regulation of endopeptidase activity positive regulation of cell growth positive regulation of protein autophosphorylation intracellular signal transduction positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of neurotrophin TRK receptor signaling pathway cellular response to acid chemical positive regulation of stem cell proliferation negative regulation of type B pancreatic cell apoptotic process inflammatory response aging response to radiation response to mechanical stimulus response to organic substance response to ozone response to organic cyclic compound response to lipopolysaccharide response to nicotine response to drug response to peptide hormone response to glucocorticoid response to electrical stimulus
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