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Invitrogen
NIBP Polyclonal Antibody
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Product Details
PA5-23130
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids in a range between 30-80 of mouse TLR4.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum with 50% glycerol
Contains
0.025% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence homology: 100% homologous in human (isoform CRA_A and CRA_b), chimpanzee, monkey, mouse, opossum, rat and dog; xenopus (94%).
Confocal immunofluorescence: Cells were fixed with 4% paraformaldehyde in PBS for 10 min and then permeabilized with 0.5 % Triton X-100 for 20 min at room temperature (RT). The cells were blocked with PBS containing 10 % BSA and probed with NIBP pAB for 1 hour at RT. After washing with PBS, cells were incubated with Alexa conjugated goat anti-mouse antibodies.
Target Information
NIBP is a 1246 amino acid intracellular regulatory protein. Reports suggest that NIBP physically interacts with NIK, IKK (beta), but not IKK (alpha) or IKK (gamma) and thus acts as a novel enhancer of cytokine-induced NF-(kappa) B signaling pathway. Due to its neuronal expression NIBP is considered as a potential target for modulating the NF-(kappa) B signaling cascade in neuronal pathologies dependent upon abnormal activation of this pathway. NIBP is mainly expressed in brain, muscle, heart, and kidney.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IKK2 binding protein; NIK and IKK(beta) binding protein; NIK and IKK-beta binding protein; NIK and IKK{beta} binding protein; NIK- and IKBKB-binding protein; Trafficking protein particle complex subunit 9; TRAPP 120 kDa subunit; Tularik gene 1 protein
Gene Aliases: 1810044A24Rik; 2900005P22Rik; 4632408O18Rik; IBP; IKBKBBP; KIAA1882; mKIAA1882; MRT13; NIBP; T1; TRAPPC9; TRS120; TRS130
UniProt ID: (Human) Q96Q05, (Bovine) Q32PH0, (Mouse) Q3U0M1
Entrez Gene ID: (Dog) 482058, (Chicken) 420312, (Human) 83696, (Bovine) 533451, (Mouse) 76510
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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