A suggested positive control is 293 cell lysate.
PA5-19871 can be used with blocking peptide PEP-0007.
Nuclear factor kappa B (NF-kappa-B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF-a, LPS and mitogens. A serine/threonine protein kinase which mediates NF-kappa-B activation by IL-1, TNF-a and CD95 was identified recently and designated NIK (for NF-kappa-B inducing kinase). NIK is an activator of Ikappa-B kinase alpha and beta (IKK-a and IKK-b). Therefore, NIK is a key molecule in the NF-kappa-B signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.
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Protein Aliases: FTDCR1B, HS, HSNIK, NIK; HsNIK; Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; serine/threonine protein-kinase; Serine/threonine-protein kinase NIK
Gene Aliases: FTDCR1B; HS; HSNIK; MAP3K14; NIK
UniProt ID: (Human) Q99558
Entrez Gene ID: (Human) 9020