PA5-27713 targets NIK in WB applications and shows reactivity with Human samples.
The PA5-27713 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 213 of Human NIK.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes mitogen-activated protein kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPK kinases. It participates in an NF-kappaB-inducing signaling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
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Protein Aliases: FTDCR1B; HS; HSNIK; Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; NIK; serine/threonine protein-kinase; Serine/threonine-protein kinase NIK
Gene Aliases: FTDCR1B; HS; HSNIK; MAP3K14; NIK
UniProt ID: (Human) Q99558
Entrez Gene ID: (Human) 9020