Immunogen sequence: GGKVNRALQQ VGGLKSPWRG EYKEPRHPPP NQANYHQTLH AQPRELSPRA PGPRPAEETT GRAPKLQPPL PPEPPEPNKS PPLTLSKEES GMWEPLPLSS LEPAPARNPS SPERKATVPE QELQQLEIEL FLNSLSQPFS LEEQEQILSC LSIDSLSLSD DSEKNPSKAS QSSRDTLSSG VHSWSSQAEA RSSSWNMVLA RGRPTDTPSY FNGVKVQIQS LNGEHLHIRE FHRVKVGDIA TGISSQIPAA AFSLVTKDGQ PVRYDMEVPD SGIDLQCTLA PDGSFAWSWR VKHGQLENRP; Positive Samples: Raji; Cellular Location: Cytoplasm
Nuclear factor κB (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The IκB kinase (IKKα and IKKβ) phosphorylates IκB and mediates NF-κB activation. A novel molecule in the IKK complex was recently identified and termed IKKγ/NEMO/FIP3/IKKAP1. IKKγ interacts with IKKβ and is required for the activation of IKK complex and NF-κB by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-κB activation.
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Protein Aliases: HsNIK; Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; Serine/threonine-protein kinase NIK
Gene Aliases: FTDCR1B; HS; HSNIK; MAP3K14; NIK
UniProt ID: (Human) Q99558
Entrez Gene ID: (Human) 9020