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NK3R Polyclonal Antibody
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FIGURE: 1 / 3
NK3R Antibody (600-401-DC1) in ICC/IF
Immunofluorescence Microscopy of NK3R antibody. Tissue: Human brain cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: NK3R antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Staining: NK3R as a red fluorescent signal.
Product Details
600-401-DC1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-NK3R antibody was prepared from whole rabbit serum produced by repeated immunizations with a 18 amino acid synthetic peptide from near the internal region of human NK3R.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G-protein coupled receptor; neuromedin K receptor; neurokinin 3 receptor; Neurokinin B; Neurokinin B receptor; neurokinin beta receptor; neuromedin K receptor; Neuromedin-K receptor; NK-3 receptor; NK-3R; NK3 receptor; NK3R TAC3R; NKR; Nmk-r; Tachykinin receptor 3
Gene Aliases: HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL; TACR3
UniProt ID: (Human) P29371, (Mouse) P47937
Entrez Gene ID: (Human) 6870, (Mouse) 21338
signal transduction
G-protein coupled receptor signaling pathway
tachykinin receptor signaling pathway
positive regulation of heart rate
response to estradiol
regulation of dopamine metabolic process
response to cocaine
positive regulation of blood pressure
regulation of feeding behavior
positive regulation of uterine smooth muscle contraction
positive regulation of sperm motility
neuropeptide signaling pathway
chemical synaptic transmission
hyperosmotic salinity response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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