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Proteintech
NKD2 Polyclonal Antibody
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Product Details
16699-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NKD2 Fusion Protein Ag10094 (1-311 aa encoded by BC012176)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGKLQSKHA AAARKRRESP EGDSFVASAY ASGRKGAEEA ERRARDKQEL PNGDPKEGPF REDQCPLQVA LPAEKAEGRE HPGQLLSADD GERAANREGP RGPGGQRLNI DALQCDVSVE EDDRQEWTFT LYDFDNCGKV TREDMSSLMH TIYEVVDASV NHSSGSSKTL RVKLTVSPEP SSKRKEGPPA GQDREPTRCR MEGELAEEPR VADRRLSAHV RRPSTDPQPC SERGPYCVDE NTERRNHYLD LAGIENYTSR FGPGSQLCEK RSSAPRTHSG DKARGVGLCR ELWSQAGHPQ WPGPFPSGLV AV (1-311 aa encoded by BC012176)
Target Information
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Dvl-binding protein NKD2; hNkd2; mNkd2; naked cuticle 1 homolog; naked cuticle 2 homolog; naked cuticle homolog 2; naked cuticle-2; Naked-2; NKD2, WNT signaling pathway inhibitor; Protein naked cuticle homolog 2
Gene Aliases: 2210403L10Rik; AW212591; Naked2; NKD2
UniProt ID: (Human) Q969F2, (Mouse) Q8VE28
Entrez Gene ID: (Human) 85409, (Rat) 308068, (Mouse) 72293
positive regulation of protein processing
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Golgi vesicle fusion to target membrane
protein targeting to plasma membrane
positive regulation of establishment of protein localization to plasma membrane
negative regulation of canonical Wnt signaling pathway
transport
exocytosis
Wnt signaling pathway
negative regulation of Wnt signaling pathway
protein localization to plasma membrane
positive regulation of protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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