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Invitrogen
NKG2A Polyclonal Antibody
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Product Details
PA5-102402
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KLRC1(Accession P26715), corresponding to amino acid residues M1-Y40.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total KLRC1.
Target Information
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-lectin type II protein; CD159 antigen-like family member A; CD159a; killer cell lectin-like receptor subfamily C, member 1; natural killer cell lectin; natural killer group protein 2; NK cell receptor A; NKG2-1/B activating NK receptor; NKG2-A gene; NKG2-A/B type II integral membrane protein; NKG2-A/B-activating NK receptor; NKG2-A/NKG2-B type II integral membrane protein; NKG2-B gene
Gene Aliases: CD159A; KLRC1; NKG2; NKG2A
UniProt ID: (Human) P26715
Entrez Gene ID: (Human) 3821
negative regulation of T cell mediated cytotoxicity
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
CD8-positive, gamma-delta intraepithelial T cell differentiation
immune system process
immune response-regulating cell surface receptor signaling pathway
natural killer cell inhibitory signaling pathway
cell surface receptor signaling pathway
regulation of natural killer cell activation
regulation of natural killer cell mediated cytotoxicity
innate immune response
negative regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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