Immunogen sequence: NCAMLHVRGL ISDQCGSSRI IRRGFIMLTR LVLN
Highest antigen sequence identity to the following orthologs: Mouse - 35%, Rat - 35%.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
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Protein Aliases: Killer cell lectin-like receptor subfamily C member 3; killer cell lectin-like receptor subfamily C, member 3; NK cell receptor E; NKG2-E; NKG2-E type II integral membrane protein; NKG2-E-activating NK receptor; NKG2E
Gene Aliases: KLRC3; NKG2-E; NKG2E
UniProt ID: (Human) Q07444
Entrez Gene ID: (Human) 3823