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Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: glial and testis-specific homeobox protein; homeobox 6B; Homeobox protein NK-6 homolog B; Homeobox protein Nkx-6.2; NK homeobox family 6, B; NK6 transcription factor related, locus 2
Gene Aliases: GTX; NKX6-2; NKX6.2; NKX6B
UniProt ID: (Human) Q9C056
Entrez Gene ID: (Human) 84504
Molecular Function:
DNA binding protein
helix-turn-helix transcription factor
homeobox transcription factor
nucleic acid binding
transcription factor
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