Immunogen sequence: WVSQPPEIRT LEGSSAFLPC SFNASQGRLA IGSVTWFRDE VVPGKEVRNG TPEFRGRLAP LASSRFLHDH QAELHIRDVR GHDASIYVCR VEVLGLGVGT GNGTRLVVEK EHPQLGAGTV L; Positive Samples: Rat liver; Cellular Location: Cell membrane, Single-pass type I membrane protein
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.
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Protein Aliases: Activating natural killer receptor p30; activating NK-A1 receptor; CD337; lymphocyte antigen 117; Natural cytotoxicity triggering receptor 3; Natural killer cell p30-related protein; NK receptor 1c7; NK-p30
Gene Aliases: 1C7; CD337; LY117; MALS; NCR3; NKp30
UniProt ID: (Human) O14931