NLE1 plays a role in regulating Notch activity, in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. NLE1 is required during embryogenesis for inner mass cell survival.
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Protein Aliases: FLJ10458; Notchless gene homolog; Notchless protein homolog 1; novel WD40 repeat containing protein
Gene Aliases: AL022765; BC018399; HUSSY-07; l11Jus1; l11Jus4; Nle; NLE1; RGD1308301