Immunogen sequence: TIKVWRAHDG VLCRTLQGHG HWVNTMALST DYALRTGAFE PAEASVNPQD LQGSLQELKE RALSRYNLVR GQGPERLVSG SDDFTL
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
NLE1 plays a role in regulating Notch activity, in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. NLE1 is required during embryogenesis for inner mass cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ10458; Notchless gene homolog; Notchless protein homolog 1; novel WD40 repeat containing protein
Gene Aliases: AL022765; BC018399; HUSSY-07; l11Jus1; l11Jus4; Nle; NLE1; RGD1308301