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Product Details
PA5-53850
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NLE1. Recombinant protein control fragment (Product #RP-92396).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2644710
Product Specific Information
Immunogen sequence: TIKVWRAHDG VLCRTLQGHG HWVNTMALST DYALRTGAFE PAEASVNPQD LQGSLQELKE RALSRYNLVR GQGPERLVSG SDDFTL
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
NLE1 plays a role in regulating Notch activity, in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. NLE1 is required during embryogenesis for inner mass cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ10458; Notchless gene homolog; Notchless protein homolog 1
Gene Aliases: HUSSY-07; Nle; NLE1
UniProt ID: (Human) Q9NVX2
Entrez Gene ID: (Human) 54475
somitogenesis
kidney development
inner cell mass cell differentiation
Notch signaling pathway
ribosomal large subunit biogenesis
negative regulation of mitotic cell cycle
skeletal system morphogenesis
hematopoietic stem cell homeostasis
positive regulation of canonical Wnt signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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