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Invitrogen
NLRC4 Polyclonal Antibody
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Product Details
PA1-4264
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic Peptide corresponding to the N-terminal sequence M N F I K D N S R A L I Q R M G M
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-4264 detects CLAN protein from human samples. This antibody detects both A and B isoforms.
PA1-4264 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~116 kDa protein representing CLAN-A and a ~43 kDa protein representing CLAN-B in lung lysate.
PA1-4264 immunizing peptide corresponds to N-terminal sequence M N F I K D N S R A L I Q R M G M.
Target Information
NLRC4 encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CARD protein; CARD, LRR, and NACHT-containing protein; CARD12; CARD12; CED4/Apaf-1 family member; caspase recruitment domain family, member 12; Caspase recruitment domain-containing protein 12; CED-4-like protein Clan; Ice protease-activating factor; ICE-protease activating factor; Ipaf; IPAF; CED4/Apaf-1 family member; NLR family CARD domain-containing protein 4; NOD-like receptor C4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4; unnamed protein product
Gene Aliases: AIFEC; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; FCAS4; IPAF; NLRC4; UNQ6189/PRO20215
UniProt ID: (Human) Q9NPP4
Entrez Gene ID: (Human) 58484
activation of innate immune response
pattern recognition receptor signaling pathway
immune system process
apoptotic process
inflammatory response
positive regulation of protein processing
detection of bacterium
positive regulation of interleukin-1 beta production
defense response to bacterium
regulation of apoptotic process
positive regulation of apoptotic process
innate immune response
icosanoid biosynthetic process
positive regulation of inflammatory response
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
pyroptosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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