Search

  • Contáctenos
  • Orden Rápida

Rockland

NLRP3 Polyclonal Antibody

View all (31) NLRP3 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:

{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
NLRP3 Polyclonal Antibody

Product Details

600-401-R14

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NLRP3 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a sequence at the N-terminal of human NLRP3.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 µg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: caterpiller protein 1.1; cold auto-inflammatory syndrome 1; PYPAF1; NALP3; C1ORF7; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein; cold autoinflammatory syndrome 1 protein homolog; cold-induced autoinflammatory syndrome 1 protein; cryopyrin; cryopyrin, NACHT, LRR and PYD domains - containing protein 3; deafness, autosomal dominant 34; FLJ95925; mast cell maturation-associated-inducible protein 1; member of the NALP family of inflammatory mediators; MMIG-1; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; PYD, NACHT, and LRR containing protein; PYRIN-containing APAF1-like protein 1; unnamed protein product

View more View less

Gene Aliases: AGTAVPRL; AII; AII/AVP; AVP; C1orf7; CIAS1; CLR1.1; DFNA34; FCAS; FCAS1; FCU; KEFH; Mmig1; MWS; NALP3; PYPAF1

View more View less

UniProt ID: (Human) Q96P20, (Mouse) Q8R4B8, (Rat) D4A523

View more View less

Entrez Gene ID: (Human) 114548, (Mouse) 216799, (Rat) 287362

View more View less

Function(s)
protein binding ATP binding ATPase activity protein binding, bridging signaling adaptor activity identical protein binding peptidoglycan binding ADP binding sequence-specific DNA binding binding, bridging phosphatidylinositol-4-phosphate binding DNA-binding transcription factor binding small molecule sensor activity cysteine-type endopeptidase activator activity molecular condensate scaffold activity phosphatidylinositol phosphate binding
Process(es)
pattern recognition receptor signaling pathway acute inflammatory response negative regulation of acute inflammatory response positive regulation of cytokine production involved in immune response positive regulation of type 2 immune response inflammatory response osmosensory signaling pathway protein secretion detection of biotic stimulus response to virus negative regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-13 production positive regulation of interleukin-18 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production interleukin-18-mediated signaling pathway NLRP3 inflammasome complex assembly response to ethanol positive regulation of T-helper 2 cell differentiation positive regulation of transcription from RNA polymerase II promoter regulation of inflammatory response negative regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-positive bacterium protein homooligomerization protein maturation defense response to virus pyroptosis interleukin-1-mediated signaling pathway cellular response to lipopolysaccharide cellular response to peptidoglycan cellular response to virus positive regulation of NLRP3 inflammasome complex assembly negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of T-helper 17 cell differentiation positive regulation of T-helper 2 cell cytokine production apoptotic process defense response signal transduction
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support