Proteintech

NLRX1 Polyclonal Antibody

NLRX1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 16

NLRX1 Antibody (17215-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using NLRX1 antibody 17215-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

NLRX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

NLRX1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17215-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NLRX1 Fusion Protein Ag11000 (359-708 aa encoded by BC013199)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EAVAQAMVL EMFREEDYYN DDVLDQMGAS ILGVEGPRRH PDEPPEDEVF ELFPMFMGGL LSAHNRAVLA QLGCPIKNLD ALENAQAIKK KLGKLGRQVL PPSELLDHLF FHYEFQNQRF SAEVLSSLRQ LNLAGVRMTP VKCTVVAAVL GSGRHALDEV NLASCQLDPA GLRTLLPVFL RARKLGLQLN SLGPEACKDL RDLLLHDQCQ ITTLRLSNNP LTEAGVAVLM EGLAGNTSVT HLSLLHTGLG DEGLELLAAQ LDRNRQLQEL NVAYNGAGDT AALALARAAR EHPSLELLQG VAIQMCWKLP LLPYAHLWTP RMPSHWCFLL ILMPPLPQWY DGLVAPRGRC T (359-708 aa encoded by BC013199)

Target Information

This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury.

Scientific reports

Kim HR,Kim MN,Kim EG,Leem JS,Baek SM,Lee YJ,Kim KW,Kang MJ,Song TW,Sohn MH

Wed Mar 01 00:00:00 UTC 2023

NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury.

Scientific reports

Kim HR,Kim MN,Kim EG,Leem JS,Baek SM,Lee YJ,Kim KW,Kang MJ,Song TW,Sohn MH

Wed Mar 01 00:00:00 UTC 2023

Daming capsule protects against myocardial infarction by promoting mitophagy via the SIRT1/AMPK signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Sun X,Han Y,Dong C,Qu H,Yu Y,Ju J,Bai Y,Yang B

Fri Jul 01 00:00:00 UTC 2022

Daming capsule protects against myocardial infarction by promoting mitophagy via the SIRT1/AMPK signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Sun X,Han Y,Dong C,Qu H,Yu Y,Ju J,Bai Y,Yang B

Fri Jul 01 00:00:00 UTC 2022

Sex-Biased Control of Inflammation and Metabolism by a Mitochondrial Nod-Like Receptor.

Frontiers in immunology

Snäkä T,Bekkar A,Desponds C,Prével F,Claudinot S,Isorce N,Teixeira F,Grasset C,Xenarios I,Lopez-Mejia IC,Fajas L,Fasel N

Fri Jun 03 00:00:00 UTC 2022

The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages.

In vitro cellular & developmental biology. Animal

Chen L,Li Y,Zeng S,Duan S,Huang Z,Liang Y

Sun May 01 00:00:00 UTC 2022

The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages.

In vitro cellular & developmental biology. Animal

Chen L,Li Y,Zeng S,Duan S,Huang Z,Liang Y

Sun May 01 00:00:00 UTC 2022

The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages.

In vitro cellular & developmental biology. Animal

Chen L,Li Y,Zeng S,Duan S,Huang Z,Liang Y

Sun May 01 00:00:00 UTC 2022

Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1.

Molecular cell

Killackey SA,Bi Y,Soares F,Hammi I,Winsor NJ,Abdul-Sater AA,Philpott DJ,Arnoult D,Girardin SE

Thu Aug 04 00:00:00 UTC 2022

NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.

Science progress

Jiao Q,Xu W,Guo X,Liu H,Liao B,Zhu X,Chen C,Yang F,Wu L,Xie C,Peng L

Fri Oct 01 00:00:00 UTC 2021

NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.

Science progress

Jiao Q,Xu W,Guo X,Liu H,Liao B,Zhu X,Chen C,Yang F,Wu L,Xie C,Peng L

Fri Oct 01 00:00:00 UTC 2021

Veterinary microbiology

Xu X,Zhang D,Ding W,Wang W,Jin N,Ding Z

Wed Sep 01 00:00:00 UTC 2021

The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1.

Molecular and cellular biochemistry

Killackey SA,Rahman MA,Soares F,Zhang AB,Abdel-Nour M,Philpott DJ,Girardin SE

Fri Mar 01 00:00:00 UTC 2019

The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1.

Molecular and cellular biochemistry

Killackey SA,Rahman MA,Soares F,Zhang AB,Abdel-Nour M,Philpott DJ,Girardin SE

Fri Mar 01 00:00:00 UTC 2019

Nucleotide-binding oligomerization domain-like receptor X1 restricts porcine reproductive and respiratory syndrome virus-2 replication by interacting with viral Nsp9.

Virus research

Jing H,Song T,Cao S,Sun Y,Wang J,Dong W,Zhang Y,Ding Z,Wang T,Xing Z,Bao W

Mon Jul 15 00:00:00 UTC 2019

Nucleotide-binding oligomerization domain-like receptor X1 restricts porcine reproductive and respiratory syndrome virus-2 replication by interacting with viral Nsp9.

Virus research

Jing H,Song T,Cao S,Sun Y,Wang J,Dong W,Zhang Y,Ding Z,Wang T,Xing Z,Bao W

Mon Jul 15 00:00:00 UTC 2019

Activation of NLRX1-mediated autophagy accelerates the ototoxic potential of cisplatin in auditory cells.

Toxicology and applied pharmacology

Yin H,Yang Q,Cao Z,Li H,Yu Z,Zhang G,Sun G,Man R,Wang H,Li J

Thu Mar 15 00:00:00 UTC 2018

Activation of NLRX1-mediated autophagy accelerates the ototoxic potential of cisplatin in auditory cells.

Toxicology and applied pharmacology

Yin H,Yang Q,Cao Z,Li H,Yu Z,Zhang G,Sun G,Man R,Wang H,Li J

Thu Mar 15 00:00:00 UTC 2018

Activation of NLRX1-mediated autophagy accelerates the ototoxic potential of cisplatin in auditory cells.

Toxicology and applied pharmacology

Yin H,Yang Q,Cao Z,Li H,Yu Z,Zhang G,Sun G,Man R,Wang H,Li J

Thu Mar 15 00:00:00 UTC 2018

Activation of NLRX1-mediated autophagy accelerates the ototoxic potential of cisplatin in auditory cells.

Toxicology and applied pharmacology

Yin H,Yang Q,Cao Z,Li H,Yu Z,Zhang G,Sun G,Man R,Wang H,Li J

Thu Mar 15 00:00:00 UTC 2018

NLRX1 Facilitates Histoplasma capsulatum-Induced LC3-Associated Phagocytosis for Cytokine Production in Macrophages.

Frontiers in immunology

Huang JH,Liu CY,Wu SY,Chen WY,Chang TH,Kan HW,Hsieh ST,Ting JP,Wu-Hsieh BA

Thu Oct 03 00:00:00 UTC 2019

NLRX1 Facilitates Histoplasma capsulatum-Induced LC3-Associated Phagocytosis for Cytokine Production in Macrophages.

Frontiers in immunology

Huang JH,Liu CY,Wu SY,Chen WY,Chang TH,Kan HW,Hsieh ST,Ting JP,Wu-Hsieh BA

Thu Oct 03 00:00:00 UTC 2019

Regulatory NLRs Control the RLR-Mediated Type I Interferon and Inflammatory Responses in Human Dendritic Cells.

Frontiers in immunology

Fekete T,Bencze D,Szabo A,Csoma E,Biro T,Bacsi A,Pazmandi K

Thu Oct 03 00:00:00 UTC 2019

Regulatory NLRs Control the RLR-Mediated Type I Interferon and Inflammatory Responses in Human Dendritic Cells.

Frontiers in immunology

Fekete T,Bencze D,Szabo A,Csoma E,Biro T,Bacsi A,Pazmandi K

Thu Oct 03 00:00:00 UTC 2019

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity.

The Journal of experimental medicine

Stokman G,Kors L,Bakker PJ,Rampanelli E,Claessen N,Teske GJD,Butter L,van Andel H,van den Bergh Weerman MA,Larsen PWB,Dessing MC,Zuurbier CJ,Girardin SE,Florquin S,Leemans JC

Mon Aug 07 00:00:00 UTC 2017

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity.

The Journal of experimental medicine

Stokman G,Kors L,Bakker PJ,Rampanelli E,Claessen N,Teske GJD,Butter L,van Andel H,van den Bergh Weerman MA,Larsen PWB,Dessing MC,Zuurbier CJ,Girardin SE,Florquin S,Leemans JC

Mon Aug 07 00:00:00 UTC 2017

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity.

The Journal of experimental medicine

Stokman G,Kors L,Bakker PJ,Rampanelli E,Claessen N,Teske GJD,Butter L,van Andel H,van den Bergh Weerman MA,Larsen PWB,Dessing MC,Zuurbier CJ,Girardin SE,Florquin S,Leemans JC

Mon Aug 07 00:00:00 UTC 2017

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity.

The Journal of experimental medicine

Stokman G,Kors L,Bakker PJ,Rampanelli E,Claessen N,Teske GJD,Butter L,van Andel H,van den Bergh Weerman MA,Larsen PWB,Dessing MC,Zuurbier CJ,Girardin SE,Florquin S,Leemans JC

Mon Aug 07 00:00:00 UTC 2017

FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1.

PLoS pathogens

Kim JH,Park ME,Nikapitiya C,Kim TH,Uddin MB,Lee HC,Kim E,Ma JY,Jung JU,Kim CJ,Lee JS

Mon May 01 00:00:00 UTC 2017

FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1.

PLoS pathogens

Kim JH,Park ME,Nikapitiya C,Kim TH,Uddin MB,Lee HC,Kim E,Ma JY,Jung JU,Kim CJ,Lee JS

Mon May 01 00:00:00 UTC 2017

FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1.

PLoS pathogens

Kim JH,Park ME,Nikapitiya C,Kim TH,Uddin MB,Lee HC,Kim E,Ma JY,Jung JU,Kim CJ,Lee JS

Mon May 01 00:00:00 UTC 2017

NLRX1 accelerates cisplatin-induced ototoxity in HEI-OC1 cells via promoting generation of ROS and activation of JNK signaling pathway.

Scientific reports

Yin H,Sun G,Yang Q,Chen C,Qi Q,Wang H,Li J

Mon Mar 13 00:00:00 UTC 2017

NLRX1 accelerates cisplatin-induced ototoxity in HEI-OC1 cells via promoting generation of ROS and activation of JNK signaling pathway.

Scientific reports

Yin H,Sun G,Yang Q,Chen C,Qi Q,Wang H,Li J

Mon Mar 13 00:00:00 UTC 2017

NLRX1 accelerates cisplatin-induced ototoxity in HEI-OC1 cells via promoting generation of ROS and activation of JNK signaling pathway.

Scientific reports

Yin H,Sun G,Yang Q,Chen C,Qi Q,Wang H,Li J

Mon Mar 13 00:00:00 UTC 2017

NLRX1 accelerates cisplatin-induced ototoxity in HEI-OC1 cells via promoting generation of ROS and activation of JNK signaling pathway.

Scientific reports

Yin H,Sun G,Yang Q,Chen C,Qi Q,Wang H,Li J

Mon Mar 13 00:00:00 UTC 2017

Mitochondrial DNA stress primes the antiviral innate immune response.

Nature

West AP,Khoury-Hanold W,Staron M,Tal MC,Pineda CM,Lang SM,Bestwick M,Duguay BA,Raimundo N,MacDuff DA,Kaech SM,Smiley JR,Means RE,Iwasaki A,Shadel GS

Thu Apr 23 00:00:00 UTC 2015

Mitochondrial DNA stress primes the antiviral innate immune response.

Nature

West AP,Khoury-Hanold W,Staron M,Tal MC,Pineda CM,Lang SM,Bestwick M,Duguay BA,Raimundo N,MacDuff DA,Kaech SM,Smiley JR,Means RE,Iwasaki A,Shadel GS

Thu Apr 23 00:00:00 UTC 2015

Nlrx1 regulates neuronal cell death.

Molecular brain

Imbeault E,Mahvelati TM,Braun R,Gris P,Gris D

Wed Dec 24 00:00:00 UTC 2014

Nlrx1 regulates neuronal cell death.

Molecular brain

Imbeault E,Mahvelati TM,Braun R,Gris P,Gris D

Wed Dec 24 00:00:00 UTC 2014

Nlrx1 regulates neuronal cell death.

Molecular brain

Imbeault E,Mahvelati TM,Braun R,Gris P,Gris D

Wed Dec 24 00:00:00 UTC 2014

Nlrx1 regulates neuronal cell death.

Molecular brain

Imbeault E,Mahvelati TM,Braun R,Gris P,Gris D

Wed Dec 24 00:00:00 UTC 2014

The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis.

The Journal of biological chemistry

Soares F,Tattoli I,Rahman MA,Robertson SJ,Belcheva A,Liu D,Streutker C,Winer S,Winer DA,Martin A,Philpott DJ,Arnoult D,Girardin SE

Fri Jul 11 00:00:00 UTC 2014

The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis.

The Journal of biological chemistry

Soares F,Tattoli I,Rahman MA,Robertson SJ,Belcheva A,Liu D,Streutker C,Winer S,Winer DA,Martin A,Philpott DJ,Arnoult D,Girardin SE

Fri Jul 11 00:00:00 UTC 2014

NLRX1 does not inhibit MAVS-dependent antiviral signalling.

Innate immunity

Soares F,Tattoli I,Wortzman ME,Arnoult D,Philpott DJ,Girardin SE

Mon Mar 24 00:00:00 UTC 2014

NLRX1 does not inhibit MAVS-dependent antiviral signalling.

Innate immunity

Soares F,Tattoli I,Wortzman ME,Arnoult D,Philpott DJ,Girardin SE

Mon Mar 24 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Caterpiller protein 11.3; CLR11.3; FLJ21478; MGC131937; MGC21025; NLR family member X1; NOD-like receptor X1; nucleotide-binding domain and leucine-rich repeat containing; nucleotide-binding oligomerization domain protein 26; Nucleotide-binding oligomerization domain protein 5; Nucleotide-binding oligomerization domain protein 9; nucleotide-binding oligomerization domain, leucine rich repeat containing X1; OTTHUMP00000205768; OTTHUMP00000205769

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Gene Aliases: BC034204; CLR11.3; DLNB26; NLRX1; NOD26; NOD5; NOD9

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UniProt ID: (Human) Q86UT6, (Mouse) Q3TL44

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Entrez Gene ID: (Human) 79671, (Mouse) 270151

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Function(s)

protein binding ATP binding nucleotide binding scaffold/adaptor protein

Process(es)

viral process negative regulation of type I interferon production negative regulation of interferon-beta production negative regulation of interleukin-6 production negative regulation of RIG-I signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling innate immune response negative regulation of innate immune response negative regulation of inflammatory response immune system process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NLRX1 Polyclonal Antibody

NLRX1 Antibody (17215-1-AP) in ICC/IF

Product Details

17215-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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