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Invitrogen

NMDAR1 Polyclonal Antibody

1 Published Figure
1 Reference
View all (49) NMDAR1 antibodies

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Product Details

PA5-85751

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Dog, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide encompassing a sequence within the Extracellular domain of mouse NMDAR1. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.37 mg/mL

Amount

137 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792888

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%).

Positive Control: mouse brain, mouse fetal brain, rat brain.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Glun1r; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; glutamate receptor subunit zeta 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor 1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; RP11-350O14.1; unnamed protein product

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Gene Aliases: GluN1; GluRdelta1; GluRzeta1; M100174; NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174

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UniProt ID: (Dog) Q5R1P0, (Rat) P35439, (Mouse) P35438

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Entrez Gene ID: (Dog) 494007, (Rat) 24408, (Mouse) 14810

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Function(s)
NMDA glutamate receptor activity glycine binding beta-amyloid binding ionotropic glutamate receptor activity receptor binding ion channel activity cation channel activity calcium channel activity calcium ion binding protein binding calmodulin binding ligand-gated ion channel activity ligand-gated sodium channel activity glutamate binding enzyme binding phosphatase binding transmitter-gated ion channel activity voltage-gated cation channel activity glutamate-gated calcium ion channel activity glutamate receptor binding signaling receptor activity macromolecular complex binding ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ionotropic glutamate receptor binding transmembrane signal receptor
Process(es)
ion transmembrane transport protein heterotetramerization conditioned taste aversion response to hypoxia startle response suckling behavior response to amphetamine ion transport cation transport calcium ion transport cellular calcium ion homeostasis positive regulation of cytosolic calcium ion concentration chemical synaptic transmission learning or memory learning memory long-term memory associative learning adult locomotory behavior olfactory learning visual learning positive regulation of calcium ion transport into cytosol regulation of cell communication response to amine propylene metabolic process sensory perception of pain calcium-mediated signaling pons maturation hypothalamus development cerebral cortex development social behavior ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic sodium ion transmembrane transport regulation of membrane potential positive regulation of apoptotic process response to morphine regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange response to ethanol positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity regulation of dendrite morphogenesis regulation of axonogenesis regulation of synapse organization neuromuscular process positive regulation of mitochondrial calcium ion concentration response to calcium ion regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic calcium ion homeostasis regulation of postsynaptic membrane potential excitatory postsynaptic potential prepulse inhibition male mating behavior response to fungicide protein-containing complex assembly calcium ion transmembrane transport cellular response to manganese ion calcium ion transmembrane import into cytosol cation transmembrane transport regulation of presynaptic membrane potential chemical synaptic transmission, postsynaptic regulation of plasma membrane bounded cell projection organization positive regulation of Schwann cell migration positive regulation of dendritic spine maintenance response to glycoside positive regulation of reactive oxygen species biosynthetic process protein localization to postsynaptic membrane regulation of cation transmembrane transport cellular response to beta-amyloid response to glycine cellular response to glycine positive regulation of excitatory postsynaptic potential rhythmic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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