|Tested species reactivity||Rat|
|Published species reactivity||Rat, Mouse, Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide from the N-terminus of the NR2A subunit of rat NMDA receptor.|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 100µg/ml BSA|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.
480031 was used in immunocytochemistry to assess how rabphilin 3A retains NMDA receptors through interaction with GluN2A/PSD-95 complex synapse sites
|Stanic J,Carta M,Eberini I,Pelucchi S,Marcello E,Genazzani AA,Racca C,Mulle C,Di Luca M,Gardoni F||Nature communications (6:null)||2015|
A de novo t(10;19)(q22.3;q13.33) leads to ZMIZ1/PRR12 reciprocal fusion transcripts in a girl with intellectual disability and neuropsychiatric alterations.
480031 was used in western blot to study translocated genes, MIZ-type containing 1 and proline-rich 12.
|Córdova-Fletes C,Domínguez MG,Delint-Ramirez I,Martínez-Rodríguez HG,Rivas-Estilla AM,Barros-Núñez P,Ortiz-López R,Neira VA||Neurogenetics (16:287)||2015|
Amino terminal domains of the NMDA receptor are organized as local heterodimers.
480031 was used in western blot to report the dimer-of-heterodimer arrangement of the GluN1/GluN2A and GluN1/GluN2B NMDA receptors.
|Lee CH,Gouaux E||PloS one (6:null)||2011|