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Invitrogen
NMDAR2A Polyclonal Antibody
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FIGURE: 1 / 18
NMDAR2A Antibody (A-6473) in IHC (F)
Immunohistochemistry using NMDA Receptor Subunit 2A Polyclonal Antibody, Rabbit: Rat brain cryosections labeled with anti-NMDA receptor, subunit 2A (rat), rabbit IgG fraction (Product # A-6473) and detected using Alexa Fluor® 488 goat anti-rabbit IgG antibody (Product # A-11008). The tissue was also labeled with Alexa Fluor® 594 anti-glial fibrillary acidic protein antibody (Product # A-21295) and counterst... View More
Product Details
A-6473
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein containing amino acid residues 1253-1391 of the C-terminal region of rat brain subunit 2A
Conjugate
Form
Lyophilized
Purification
IgG fraction
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes the 180 kDa 2A subunit from rat, mouse and human, and does not cross-react with the 2B or 2C subunits.
Storage and reconstitution: when stored at -20°C or below, the lyophilized antibody should retain full activity for over one year. Reconstitute using 50 µL PBS, pH 7.4, to yield a 0.2 mg/mL solution. If storing at 0-4°C, add sodium azide to a final concentration of 2mM. For longer storage, divide the solution into aliquots and freeze at -20°C, avoiding freeze/thaw cycles.
Target Information
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GluN2A; GluRepsilon1; Glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA Receptor 2A; NMDAR 2A; NMDAR2A; OTTHUMP00000160135; OTTHUMP00000174531
Gene Aliases: EPND; FESD; GluN2A; GRIN2A; LKS; NMDAR2A; NR2A
UniProt ID: (Human) Q12879, (Mouse) P35436, (Rat) Q63728
Entrez Gene ID: (Human) 2903, (Mouse) 14811, (Rat) 24409
NMDA glutamate receptor activity
Ras guanyl-nucleotide exchange factor activity
extracellular-glutamate-gated ion channel activity
calcium channel activity
protein binding
zinc ion binding
receptor activity
ionotropic glutamate receptor activity
receptor binding
ion channel activity
cation channel activity
glutamate binding
protein kinase binding
voltage-gated cation channel activity
protein complex binding
glutamate receptor binding
neurotransmitter binding
metal ion binding
protein heterodimerization activity
protein dimerization activity
cell adhesion molecule binding
ATPase binding
scaffold protein binding
transmembrane signal receptor
MAPK cascade
startle response
response to amphetamine
transport
glutamate receptor signaling pathway
chemical synaptic transmission
learning or memory
memory
protein localization
visual learning
response to wounding
sensory perception of pain
neurogenesis
sleep
directional locomotion
ionotropic glutamate receptor signaling pathway
negative regulation of protein catabolic process
dopamine metabolic process
serotonin metabolic process
response to drug
positive regulation of apoptotic process
positive regulation of GTPase activity
response to ethanol
regulation of sensory perception of pain
excitatory postsynaptic potential
long-term synaptic potentiation
calcium ion transmembrane transport
positive regulation of long-term synaptic potentiation
action potential
ion transport
cation transport
calcium ion transport
learning
locomotory behavior
positive regulation of cell death
ion transmembrane transport
regulation of ion transmembrane transport
synaptic transmission, glutamatergic
locomotion
regulation of membrane potential
regulation of synaptic plasticity
regulation of long-term neuronal synaptic plasticity
rhythmic process
modulation of synaptic transmission
detection of mechanical stimulus involved in sensory perception of pain
protein tetramerization
regulation of postsynaptic membrane potential
cellular response to amino acid stimulus
cellular response to zinc ion
cation transmembrane transport
positive regulation of excitatory postsynaptic potential
response to light stimulus
response to carbohydrate
response to manganese ion
response to organic cyclic compound
response to amine
spinal cord development
hippocampus development
cerebral cortex development
response to cocaine
response to calcium ion
response to methylmercury
response to other organism
response to ammonium ion
response to fungicide
cellular response to magnesium ion
cellular response to manganese ion
cellular response to dsRNA
cellular response to growth factor stimulus
cellular response to lipid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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