Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request:org.apache.struts2.dispatcher.StrutsRequestWrapper@38524588
Request attributes: pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:
syndicationDisplayType:

Invitrogen

NMDAR2A Polyclonal Antibody

6 Published Figures
13 References
View all (14) NMDAR2A antibodies
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
433BB748-DC81-4FE4-83AD-384F97313745 Created with sketchtool. Create Citation
C488C313-B559-4BFD-B17D-A8B65492815A Created with sketchtool. Tech Support
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
433BB748-DC81-4FE4-83AD-384F97313745 Created with sketchtool. Create Citation
C488C313-B559-4BFD-B17D-A8B65492815A Created with sketchtool. Tech Support

Product Details

Tested Applications
Dilution
ELISA (ELISA)
Assay Dependent
Immunofluorescence (IF)
1:500-1:5000
Immunohistochemistry (Frozen) (IHC (F))
1:500-1:5000
Immunoprecipitation (IP)
3 µL
Western Blot (WB)
1:100-1:500
Published Applications
Western Blot (WB)
See 9 publications below
Immunofluorescence (IF)
See 1 publication below
Immunohistochemistry (IHC)
See 1 publication below
Miscellaneous PubMed (MISC)
See 2 publications below
Product Specifications
Species Reactivity
Human, Mouse, Rat
Published species
Human, Mouse, Rat
Host / Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein containing amino acid residues 1253–1391 of the C-terminal region of rat brain subunit 2A
Conjugate
Unconjugated
Form
Lyophilized
Purification
IgG fraction
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C
RRID
AB_2536209

Product Specific Information

This antibody recognizes the 180 kDa 2A subunit from rat, mouse and human, and does not cross-react with the 2B or 2C subunits.

Storage and reconstitution: when stored at -20°C or below, the lyophilized antibody should retain full activity for over one year. Reconstitute using 50 µL PBS, pH 7.4, to yield a 0.2 mg/mL solution. If storing at 0-4°C, add sodium azide to a final concentration of 2mM. For longer storage, divide the solution into aliquots and freeze at -20°C, avoiding freeze/thaw cycles.

Target Information

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: GluN2A; GluRepsilon1; Glutamate [NMDA] receptor subunit epsilon-1; Glutamate NMDA receptor subunit epsilon-1; Glutamate receptor ionotropic NMDA 2A; Glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; Grin2a; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; N-Methyl-D-Aspartate Receptor Type 2A; NMDAR2A; NR2A

Gene Aliases: EPND; FESD; GluN2A; GRIN2A; LKS; NMDAR2A; NR2A

UniProt ID: (Human) Q12879, (Mouse) P35436, (Rat) Q00959

Entrez Gene ID: (Human) 2903, (Mouse) 14811, (Rat) 24409

Molecular Function: ion channel ionotropic glutamate receptor ligand-gated ion channel receptor transporter

Function(s)
MAPK cascade startle response response to amphetamine transport glutamate receptor signaling pathway chemical synaptic transmission learning or memory memory protein localization visual learning response to wounding sensory perception of pain neurogenesis sleep directional locomotion ionotropic glutamate receptor signaling pathway negative regulation of protein catabolic process dopamine metabolic process serotonin metabolic process response to drug positive regulation of apoptotic process positive regulation of GTPase activity response to ethanol regulation of sensory perception of pain excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane transport positive regulation of long-term synaptic potentiation action potential ion transport cation transport calcium ion transport learning locomotory behavior positive regulation of cell death ion transmembrane transport regulation of ion transmembrane transport synaptic transmission, glutamatergic locomotion regulation of membrane potential regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity rhythmic process modulation of synaptic transmission detection of mechanical stimulus involved in sensory perception of pain protein tetramerization regulation of postsynaptic membrane potential cellular response to amino acid stimulus cellular response to zinc ion cation transmembrane transport positive regulation of excitatory postsynaptic potential response to light stimulus response to carbohydrate response to manganese ion response to organic cyclic compound response to amine spinal cord development hippocampus development cerebral cortex development response to cocaine response to calcium ion response to methylmercury response to other organism response to ammonium ion response to fungicide cellular response to magnesium ion cellular response to manganese ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to lipid
Process(es)
NMDA glutamate receptor activity Ras guanyl-nucleotide exchange factor activity extracellular-glutamate-gated ion channel activity calcium channel activity protein binding zinc ion binding receptor activity ionotropic glutamate receptor activity receptor binding ion channel activity cation channel activity glutamate binding protein kinase binding voltage-gated cation channel activity protein complex binding glutamate receptor binding neurotransmitter binding metal ion binding protein heterodimerization activity protein dimerization activity cell adhesion molecule binding ATPase binding scaffold protein binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support
Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:
syndicationDisplayType:

 

page info