This antibody detects predominantly the NR2C isoform but may show low level cross-reactivity with the NR2A and NR2B isoforms.
In Western blot, this antibody detects a ~140 kDa protein representing NR2C in rat brain homogenate. Faint bands representing the NR2A and NR2B isoforms at 180 KDa may also be observed. Immunohistochemical staining in rat brain with OPA1-04020 yields a pattern consistent with plasma membrane staining.
Reconstitute with 50 µL of PBS.
The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GluN2C; GluRepsilon3; Glutamate [NMDA] receptor subunit epsilon-3; Glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; glutamate receptor, ionotropic, NMDA2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; N-Methyl-D-Aspartate Receptor Type 2; NMDA glutamate receptor; NMDAR; NMDAR2C
Gene Aliases: GluN2C; GRIN2C; NMDAR2C; NR2C