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Invitrogen
NMDAR2C Polyclonal Antibody
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NMDAR2C Antibody (PA5-103151) in IHC (P)
Immunohistochemistry analysis of NMDAR2C in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with NMDAR2C polyclonal antibody (Product # PA5-103151) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103151
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GRIN2C(Accession Q14957), corresponding to amino acid residues H402-L452.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NMDA epsilon 3.
Target Information
The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GluN2C; Glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor; Glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; NMDAR2C; NR2
Gene Aliases: GluN2C; GRIN2C; NMDAR2C; NR2C
UniProt ID: (Human) Q14957
Entrez Gene ID: (Human) 2905
MAPK cascade
transport
glutamate receptor signaling pathway
chemical synaptic transmission
protein localization
response to wounding
directional locomotion
ionotropic glutamate receptor signaling pathway
negative regulation of protein catabolic process
positive regulation of GTPase activity
neuromuscular process controlling balance
excitatory postsynaptic potential
cation transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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