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Invitrogen
NMDAR2C Polyclonal Antibody
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FIGURE: 1 / 2
NMDAR2C Antibody (PA5-103151) in IHC (P)
Immunohistochemistry analysis of NMDAR2C in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with NMDAR2C polyclonal antibody (Product # PA5-103151) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103151
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GRIN2C(Accession Q14957), corresponding to amino acid residues H402-L452.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NMDA epsilon 3.
Target Information
The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GluN2C; GluN2C(alt_5'UTR_77nt); GluN2C(alt_5'UTR_87nt); GluN2C(del_e2); GluN2C-b alternative isoform; Glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor; Glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; NMDAR2C; NR2; putative NMDtranscript(altAcc_e11); putative NMDtranscript(altDon_e4); putative NMDtranscript(del_e4)
Gene Aliases: GluN2C; GRIN2C; NMDAR2C; NR2C
UniProt ID: (Human) Q14957
Entrez Gene ID: (Human) 2905
ion transport
glutamate receptor signaling pathway
brain development
response to wounding
directional locomotion
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
negative regulation of protein catabolic process
regulation of membrane potential
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
neuromuscular process controlling balance
positive regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
long-term synaptic potentiation
calcium ion transmembrane import into cytosol
cation transmembrane transport
excitatory chemical synaptic transmission
protein localization to postsynaptic membrane
regulation of cation transmembrane transport
positive regulation of excitatory postsynaptic potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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