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NMDAR2D Polyclonal Antibody
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Product Details
OSN00075W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 450-500 of mouse NMDAR2D conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in at and human.
Specificity of this antibody: NMDAR2D.
Target Information
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors exhibit slow kinetsis of Ca2+ ions and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilon 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EB11; estrogen receptor binding CpG island; GluN2D; glur epsilon 4; GluRepsilon4; Glutamate [NMDA] receptor subunit epsilon-4; glutamate receptor; Glutamate receptor ionotropic, NMDA 2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; glutamate receptor, ionotropic, NMDA2D; ionotropic NMDA glutamate receptor epsilon 4 subunit type 2; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D; NMDAR2D; NR2D
Gene Aliases: DEE46; EB11; EIEE46; GluN2D; GRIN2D; NMDAR2D; NR2D
UniProt ID: (Human) O15399, (Mouse) Q03391, (Rat) Q62645
Entrez Gene ID: (Human) 2906, (Mouse) 14814, (Rat) 24412
ionotropic glutamate receptor activity
NMDA glutamate receptor activity
ion channel activity
cation channel activity
protein binding
ligand-gated ion channel activity
glutamate binding
voltage-gated cation channel activity
glutamate-gated calcium ion channel activity
signaling receptor activity
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
receptor activity
extracellular-glutamate-gated ion channel activity
neurotransmitter binding
transmembrane signal receptor
startle response
ion transport
brain development
adult locomotory behavior
calcium-mediated signaling
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
regulation of sensory perception of pain
positive regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
long-term synaptic potentiation
calcium ion transmembrane import into cytosol
cation transmembrane transport
excitatory chemical synaptic transmission
regulation of presynaptic membrane potential
regulation of cation transmembrane transport
cellular response to L-glutamate
positive regulation of excitatory postsynaptic potential
transport
cation transport
regulation of ion transmembrane transport
detection of mechanical stimulus involved in sensory perception of pain
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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