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Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse and shares 92% identity with human sequence.
Specificity of this antibody: NMDAR3A.
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Grin3a is mediated by glycine and may play a role in the development of dendritic spines. Further, Grin3a may play a role in PPP2CB-NMDAR mediated signaling mechanism. Grin3a belongs to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. Grin3a shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in Grin3a suggest that the protein may be involved in the development of synaptic elements by modulating NMDA receptor activity. Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GluN3A; glutamate receptor; Glutamate receptor chi-1; Glutamate receptor ionotropic, NMDA 3A; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subtype 3A; NMDAR-L; NMDAR-L1; NMDAR3A
Gene Aliases: 6430537F04; A830097C19Rik; chi-1; GluN3A; Grin3a; Kiaa1973; mKIAA1973; NMDAR-L; NR3; NR3A
Molecular Function: transmembrane signal receptor