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NMDAR3A Polyclonal Antibody
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NMDAR3A Antibody (OSN00101W-100UL) in IHC (P)
IHC on paraffin sections of rat spinal cord tissue using Rabbit antibody to NMDAR3A (990-1040): OSN00101W. HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1:1000, incubated 30 min at RT (using Autostainer). Sections were counters... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
OSN00101W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 990-1040 of rat NMDAR3A conjugated to blue carrier protein was used as the antigen
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide shares 95% identity with mouse sequence.
Specificity of this antibody: NMDAR3A.
Target Information
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Grin3a is mediated by glycine and may play a role in the development of dendritic spines. Further, Grin3a may play a role in PPP2CB-NMDAR mediated signaling mechanism. Grin3a belongs to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. Grin3a shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in Grin3a suggest that the protein may be involved in the development of synaptic elements by modulating NMDA receptor activity. Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: glutamate [NMDA] receptor subunit 3A; glutamate receptor; glutamate receptor chi-1; glutamate receptor subunit; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR-L; NMDAR-L1; NMDAR3A; NR3 chi-1; NR3A
Gene Aliases: chi-1; GluN3A; NR3
UniProt ID: (Rat) Q9R1M7
Entrez Gene ID: (Rat) 191573
NMDA glutamate receptor activity
ion channel activity
calcium channel activity
protein binding
glutamate receptor activity
ligand-gated ion channel activity
glycine binding
transmitter-gated ion channel activity
signaling receptor activity
identical protein binding
protein phosphatase 2A binding
serine binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ion transport
calcium ion transport
brain development
dendrite development
trigeminal motor nucleus development
mesencephalic trigeminal nucleus development
hippocampus development
hypothalamus development
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
response to ethanol
regulation of synaptic plasticity
modulation of synaptic transmission
regulation of postsynaptic membrane potential
prepulse inhibition
negative regulation of dendritic spine development
calcium ion transmembrane transport
cation transmembrane transport
presynaptic modulation of chemical synaptic transmission
negative regulation of dendritic spine maintenance
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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