NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34(+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.
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Protein Aliases: c371H6.2; DR nm23; DR-nm23; expressed in non-metastatic cells 3; expressed in non-metastatic cells 3 protein (nucleoside diphosphate kinase); expressed in non-metastatic cells 3, protein (nucleoside diphosphate kinase); KIAA0516; NDK 3; NDP kinase 3; NDP kinase C; NDPK C; NDPKC; nm23-H3; nm23-M3; NME3; non-metastatic cell expressed protein 3; non-metastatic cells 3, protein expressed in; Nucleoside diphosphate kinase 3; Nucleoside diphosphate kinase C; nucleoside diphosphate kinase DR-nm23
Gene Aliases: 1810009F08Rik; AI413736; c371H6.2; DR-nm23; Ndk3; NDPK-C; NDPKC; NM23-dr; NM23-H3; Nm23-M3; NM23H3; NME3