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Proteintech
NME3 Polyclonal Antibody
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Product Details
15136-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NME3 Fusion Protein Ag7284 (22-169 aa encoded by BC000250)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ERTFLAVKP DGVQRRLVGE IVRRFERKGF KLVALKLVQA SEELLREHYA ELRERPFYGR LVKYMASGPV VAMVWQGLDV VRTSRALIGA TNPADAPPGT IRGDFCIEVG KNLIHGSDSV ESARREIALW FRADELLCWE DSAGHWLYE (22-169 aa encoded by BC000250)
Target Information
NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34(+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DR-nm23; expressed in non-metastatic cells 3; expressed in non-metastatic cells 3 protein (nucleoside diphosphate kinase); expressed in non-metastatic cells 3, protein (nucleoside diphosphate kinase); NDK 3; NDK3; NDP kinase 3; NDP kinase C; NDPK-C; NDPKC; nm23-H3; nm23-M3; non-metastatic cell expressed protein 3; non-metastatic cells 3, protein expressed in; Nucleoside diphosphate kinase 3; Nucleoside diphosphate kinase C; nucleoside diphosphate kinase DR-nm23
Gene Aliases: 1810009F08Rik; AI413736; c371H6.2; DR-nm23; Ndk3; NDPK-C; NDPKC; NM23-dr; NM23-H3; Nm23-M3; NM23H3; NME3
UniProt ID: (Human) Q13232, (Mouse) Q9WV85
Entrez Gene ID: (Human) 4832, (Rat) 85269, (Mouse) 79059
GTP biosynthetic process
UTP biosynthetic process
dTTP biosynthetic process
CTP biosynthetic process
DNA repair
apoptotic process
mitochondrial fusion
nucleotide metabolic process
nucleoside triphosphate biosynthetic process
protein hexamerization
mitochondrial outer membrane fusion
purine nucleotide metabolic process
nucleoside diphosphate phosphorylation
pyrimidine nucleotide metabolic process
biological_process
regulation of apoptotic process
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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