PA5-28793 targets nm23-H3 in WB applications and shows reactivity with Human samples. Predicted to react with Mouse and Rat based on 100% sequence homology.
The PA5-28793 immunogen is synthetic peptide corresponding to a region within amino acids 106 and 169 of Human nm23-H3.
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Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
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Protein Aliases: c371H6.2; DR-nm23; NDK 3; NDP kinase 3; NDP kinase C; NDPK-C; NDPKC; NM23-H3; NM23H3; non-metastatic cells 3, protein expressed in; Nucleoside diphosphate kinase 3; Nucleoside diphosphate kinase C
Gene Aliases: c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3; NM23H3; NME3
UniProt ID: (Human) Q13232
Entrez Gene ID: (Human) 4832