Immunogen sequence: VDPWESEQAQ WMETVKVLRH HHSKLLRSPP QMEGPDHGKA LFSTPAAVPE LKLLCGADVL KTFQTPNLWK DAHIQEIVEK FGLVCV
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 83%.
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NaMN adenylyltransferase 3; Nicotinamide mononucleotide adenylyltransferase 3; Nicotinamide-nucleotide adenylyltransferase 3; Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3; Nicotinate-nucleotide adenylyltransferase 3; NMN adenylyltransferase 3; NMN/NaMN adenylyltransferase 3; NMNAT3; PNAT-3; Pyridine nucleotide adenylyltransferase 3
Gene Aliases: FKSG76; NMNAT3; PNAT-3; PNAT3
UniProt ID: (Human) Q96T66
Entrez Gene ID: (Human) 349565