Immunogen sequence: MADESETAVK PPAPPLPQMM EGNGNGHEHC SDCENEEDNS YNRGGLSPAN DTGAK
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 220.127.116.11) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).
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Protein Aliases: alternative; alternative, short form NMT-S; Glycylpeptide N-tetradecanoyltransferase 1; long form; long form, NMT-L; Myristoyl-CoA:protein N-myristoyltransferase 1; NMT 1; NMT-L; Peptide N-myristoyltransferase 1; short form NMT-S; type I N-myristoyltransferase
Gene Aliases: NMT; NMT1
UniProt ID: (Human) P30419
Entrez Gene ID: (Human) 4836
Molecular Function: transferase