This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide.
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Protein Aliases: Neuromedin precursor-related peptide 33; Neuromedin precursor-related peptide 36; Neuromedin-U; Neuromedin-U-25; NmU 25; NmU-25; NURP33; NURP36; prepro-NMU
Gene Aliases: NMU
UniProt ID: (Human) P48645
Entrez Gene ID: (Human) 10874