Immunogen sequence: NRSLANVILG GYGTTSTAGG KPMEISGTHT EINLDNAIDM IREANSIIIT PGYGLCAAKA QYPIADLVKM LTEQGKKVRF GIHPVAGRMP GQLNVLLAEA GVPYDIVLEM DEINHDFPDT DLVLVIGAND TVNSAAQEDP NSIIAGMPVL EVWKSKQVIV MKRSLGVGYA AVDNPIFYKP NTAMLLGDAK KTCDALQAKV RESYQK; Positive Samples: HepG2, Mouse heart, Mouse liver, Rat kidney; Cellular Location: Matrix side, Mitochondrion inner membrane, Multi-pass membrane protein
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: NAD(P) transhydrogenase, mitochondrial; Nicotinamide nucleotide transhydrogenase; Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase); Pyridine nucleotide transhydrogenase
Gene Aliases: 4930423F13Rik; AI323702; BB168308; GCCD4; NNT
UniProt ID: (Human) Q13423