PA5-31439 targets NO66 in WB applications and shows reactivity with Human samples.
The PA5-31439 immunogen is recombinant fragment corresponding to a region within amino acids 452 and 641 of Human NO66.
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Histone demethylase that specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region.
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Protein Aliases: 60S ribosomal protein L8 histidine hydroxylase; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; Histone lysine demethylase NO66; hsNO66; lysine-specific demethylase NO66; MAPJD; MYC-associated protein with JmjC domain; NO66; Nucleolar protein 66; Ribosomal oxygenase 1; Ribosomal oxygenase NO66; ROX; up-regulated in lung cancer 2
Gene Aliases: C14orf169; hsNO66; MAPJD; NO66; RIOX1; ROX; URLC2
UniProt ID: (Human) Q9H6W3
Entrez Gene ID: (Human) 79697