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Invitrogen
NOD3 Polyclonal Antibody
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Product Details
PA5-21016
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the center of human NOD3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is NIH-3T3 cell lysate.
PA5-21016 can be used with blocking peptide PEP-1130.
Target Information
NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CARD15-like protein; caterpillar 16.2; Caterpiller 16.2; Caterpiller protein 16.2; CLR16.2; NACHT, LRR and CARD domains-containing protein 3; NLR family CARD domain-containing protein 3; NLR family, CARD domain containing 3; NLR family, CARD domain containing 3, pseudogene 1; NOD-like receptor C3; Nucleotide-binding oligomerization domain protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3; Protein NLRC3
Gene Aliases: CLR16.2; D230007K08Rik; mFLJ00348; NLRC3; Nlrc3-ps1; NOD3; RGD1304902
UniProt ID: (Human) Q7RTR2, (Mouse) Q5DU56
Entrez Gene ID: (Human) 197358, (Rat) 287070, (Mouse) 268857
negative regulation of immune system process
I-kappaB kinase/NF-kappaB signaling
negative regulation of NF-kappaB transcription factor activity
negative regulation of interferon-alpha production
negative regulation of interferon-beta production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
T cell activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of innate immune response
negative regulation of innate immune response
negative regulation of fibroblast proliferation
negative regulation of epithelial cell proliferation
negative regulation of inflammatory response
negative regulation of protein kinase B signaling
regulation of primary metabolic process
negative regulation of cytokine production involved in inflammatory response
negative regulation of NLRP3 inflammasome complex assembly
negative regulation of NIK/NF-kappaB signaling
regulation of protein ubiquitination
response to lipopolysaccharide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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