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Immunogen sequence: SNDSRIQRHRK ALLSKVGGGP ELGGPWHRLA SLLLVEGLTD LQLREHDFTQ VEATRGGGHP ARTVALDRLF LPLSRVSVPP RVSITIGV
Highest antigen sequence identity to the following orthologs - mouse 79%, rat 74%.
NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CARD15-like protein; Caterpiller protein 16.2; CLR16.2; NACHT, LRR and CARD domains-containing protein 3; NLR family CARD domain-containing protein 3; NLR family, CARD domain containing 3; NOD-like receptor C3; Nucleotide-binding oligomerization domain protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3
Gene Aliases: CLR16.2; NLRC3; NOD3
UniProt ID: (Human) Q7RTR2
Entrez Gene ID: (Human) 197358
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