Invitrogen

NOR-1 Polyclonal Antibody

View all (29) NOR-1 antibodies

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NOR-1 Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry analysis of NOR-1 in COLO205. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115670) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with Alexa Fluor 594 conjugated goat anti-rabbit IgG using a dilution of 1:600.

NOR-1 Antibody in Western Blot (WB) — Western blot analysis of NOR-1 in COLO cells (left lane: treated with antigen-specific peptide). Samples were incubated with polyclonal antibody (Product # PA5-115670).

Product Details

PA5-115670

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	-
Immunocytochemistry (ICC/IF)	1:100-1:500	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A synthesized peptide derived from human NR4A3(Accession Q92570), corresponding to amino acid residues R404-D423. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS with 50% glycerol, 150mM NaCl
Contains	0.02% sodium azide
Storage conditions	-20°C

Target Information

NOR-1, a NR4 nerve growth factor-like receptor, has been shown to affect neuronal development, T-cell apoptosis, and cancer development. NOR-1 binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 is induced rapidly but transiently by a variety of stimuli. Downregulation of NOR-1 and other NGFI-B family members is correlated with drug addiction-prone behavior of Lewis rats. Three human protein isoforms have been documented: NOR-1, NOR-1beta, and NOR-1 3' variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: chondrosarcoma, extraskeletal myxoid, fused to EWS; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Neuron-derived orphan receptor 1/2; Nuclear hormone receptor NOR-1; Nuclear hormone receptor NOR-1/NOR-2; Nuclear receptor subfamily 4 group A member 3; nuclear receptor subfamily 4, group A, member 3; Orphan nuclear receptor TEC; TEC receptor; Translocated in extraskeletal chondrosarcoma

Gene Aliases: AI573420; CHN; CSMF; MINOR; NOR-1; NOR-2; NOR1; NR4A3; TEC

UniProt ID: (Human) Q92570, (Rat) P51179, (Mouse) Q9QZB6

Entrez Gene ID: (Human) 8013, (Rat) 58853, (Mouse) 18124

Molecular Function: C4 zinc finger nuclear receptor

negative regulation of transcription from RNA polymerase II promoter mesoderm formation transcription initiation from RNA polymerase II promoter gastrulation axon guidance biological_process pyruvate oxidation positive regulation of cardiac muscle hypertrophy positive regulation of glucose transport hippocampus development intracellular receptor signaling pathway adult behavior organ regeneration positive regulation of mast cell cytokine production common myeloid progenitor cell proliferation positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway response to hydrogen peroxide mast cell degranulation steroid hormone mediated signaling pathway negative regulation of neuron apoptotic process cellular response to leptin stimulus cellular respiration fat cell differentiation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation semicircular canal morphogenesis positive regulation of epithelial cell proliferation neuromuscular process controlling balance vestibular reflex regulation of type B pancreatic cell proliferation cellular response to corticotropin-releasing hormone stimulus cellular response to catecholamine stimulus energy homeostasis positive regulation of monocyte aggregation negative regulation of hydrogen peroxide-induced neuron death positive regulation of leukocyte apoptotic process positive regulation of feeding behavior regulation of energy homeostasis transcription, DNA-templated transcription from RNA polymerase II promoter inner ear morphogenesis negative regulation of apoptotic process response to peptide hormone

Process(es)

RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription coactivator binding DNA binding steroid hormone receptor activity thyroid hormone receptor activity protein binding zinc ion binding protein kinase binding histone acetyltransferase binding glucocorticoid receptor binding protein homodimerization activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding sequence-specific DNA binding