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Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
3-5 µg/mL | - |
Product Specifications | |
---|---|
Species Reactivity |
Bovine, Dog, Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide (1755 VLLSRKRRRQHGQC 1767) of Notch1/Notch1 cleaved protein. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Protein G |
Storage buffer |
PBS with 0.2% gelatin |
Contains |
0.05% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2540707 |
The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); major type A protein; Motch A; mT14; Neurogenic locus notch homolog protein 1; NEXT; NICD; Notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1; Notch homolog 1, translocation-associated; p300; RP23-306D20.12; RP23-306D20.12-001; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1
Gene Aliases: 9930111A19Rik; AOS5; AOVD1; hN1; lin-12; Mis6; Motch; N1; NOTCH; NOTCH1; TAN1
UniProt ID: (Human) P46531, (Mouse) Q8K428, (Rat) Q07008
Entrez Gene ID: (Bovine) 767866, (Dog) 480676, (Human) 4851, (Mouse) 18128, (Rat) 25496
Molecular Function:
extracellular matrix glycoprotein
cell adhesion molecule
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