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Invitrogen
NOTCH2 Polyclonal Antibody
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Product Details
PA5-86959
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human NOTCH2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Motch B; Neurogenic locus notch homolog protein 2; Notch 2; Notch gene homolog 2; Notch homolog 2
Gene Aliases: AGS2; AI853703; HJCYS; hN2; N2; NOTCH2
UniProt ID: (Human) Q04721, (Mouse) O35516
Entrez Gene ID: (Human) 4853, (Mouse) 18129, (Rat) 29492
cell fate determination
marginal zone B cell differentiation
pulmonary valve morphogenesis
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
apoptotic process
cell cycle arrest
Notch signaling pathway
multicellular organism development
nervous system development
negative regulation of cell proliferation
organ morphogenesis
cell growth
stem cell population maintenance
hemopoiesis
intracellular receptor signaling pathway
tissue regeneration
negative regulation of apoptotic process
positive regulation of Ras protein signal transduction
bone remodeling
regulation of developmental process
atrial septum morphogenesis
Notch signaling involved in heart development
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
liver development
placenta development
heart looping
morphogenesis of an epithelial sheet
inflammatory response to antigenic stimulus
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
humoral immune response
determination of left/right symmetry
positive regulation of cell proliferation
cell differentiation
embryonic limb morphogenesis
positive regulation of BMP signaling pathway
multicellular organism growth
intrahepatic bile duct development
wound healing
defense response to bacterium
myeloid dendritic cell differentiation
positive regulation of apoptotic process
positive regulation of osteoclast differentiation
placenta blood vessel development
ciliary body morphogenesis
left/right axis specification
hepatocyte proliferation
liver morphogenesis
interleukin-4 secretion
cholangiocyte proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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