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Invitrogen
NOTCH2 Polyclonal Antibody
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NOTCH2 Antibody (PA5149980) in IHC (P)
Immunohistochemistry analysis of NOTCH2 in paraffin-embedded Human Liver tissue. Samples were incubated with NOTCH2 Polyclonal (Product # PA5149980) antibody using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Product Details
PA5149980
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig,
Rat
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Notch Homolog 2 (NOTCH2) (Ala2251-Asn2466)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neurogenic locus notch homolog protein 2; neurogenic locus notch-like protein 2; Notch 2; notch gene homolog 2; Notch homolog 2
Gene Aliases: AGS2; HJCYS; hN2; NOTCH2
UniProt ID: (Human) Q04721
Entrez Gene ID: (Human) 4853, (Pig) 100153369, (Rat) 29492
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
cell fate determination
placenta development
heart looping
morphogenesis of an epithelial sheet
inflammatory response to antigenic stimulus
pulmonary valve morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
humoral immune response
cell cycle arrest
Notch signaling pathway
determination of left/right symmetry
positive regulation of cell proliferation
negative regulation of cell proliferation
organ morphogenesis
cell growth
embryonic limb morphogenesis
positive regulation of BMP signaling pathway
wound healing
tissue regeneration
defense response to bacterium
myeloid dendritic cell differentiation
positive regulation of apoptotic process
positive regulation of osteoclast differentiation
positive regulation of Ras protein signal transduction
bone remodeling
regulation of developmental process
atrial septum morphogenesis
placenta blood vessel development
ciliary body morphogenesis
left/right axis specification
interleukin-4 secretion
marginal zone B cell differentiation
transcription initiation from RNA polymerase II promoter
apoptotic process
multicellular organism development
nervous system development
stem cell population maintenance
hemopoiesis
intracellular receptor signaling pathway
negative regulation of apoptotic process
Notch signaling involved in heart development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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