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Recommended positive controls: THP-1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation. [UniProt]
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Notch homolog 2 N-terminal like protein; Notch homolog 2 N-terminal-like protein; Notch homolog 2 N-terminal-like protein A
Gene Aliases: N2N; NOTCH2NL; NOTCH2NLA
UniProt ID: (Human) Q7Z3S9
Entrez Gene ID: (Human) 388677
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