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Proteintech
NOTCH3 Polyclonal Antibody
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Product Details
30540-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NOTCH3 fusion protein Ag30242
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Amount
97.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SPQERPPPYL AVPGHGEEYP AAGAHSSPPK ARFLRVPSEH PYLTPSPESP EHWASPSPPS LSDWSESTPS PATATGAMAT TTGALPAQPL PLSVPSSLAQ AQTQLGPQPE VTPKRQVLA
Target Information
NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neurogenic locus notch homolog protein 3; Notch 3; Notch gene homolog 3; Notch homolog 3
Gene Aliases: AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; NOTCH3
UniProt ID: (Human) Q9UM47, (Mouse) Q61982
Entrez Gene ID: (Human) 4854, (Mouse) 18131
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
Notch signaling pathway
axon guidance
neuroblast differentiation
cell differentiation
neuron differentiation
forebrain development
negative regulation of cell differentiation
negative regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
neuron fate commitment
artery morphogenesis
regulation of developmental process
glomerular capillary formation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
transcription, DNA-templated
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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