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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide conjugated to KLH derived from within residues 2300 to the C-terminus of Human NOTCH3.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:300|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Immunohistochemistry (PFA fixed) (IHC (PFA))||Assay-Dependent|
|Western Blot (WB)||1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Heat mediated antigen retrieval recommended prior to tissue staining.
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CADASIL, CASIL, Notch homolog 3; neurogenic locus notch homolog protein 3; Notch gene homolog 3; Notch homolog 3
AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; NOTCH3