Peptide sequence: KALKPKAEVD EDGVVMCSGP EEGEEVGQAE ETGPPSTCQL WSLSGGCGAL
Sequence homology: Cow: 92%; Dog: 77%; Guinea Pig: 79%; Horse: 92%; Human: 100%; Pig: 100%; Rabbit: 79%
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases (entrez gene).
Protein Aliases: DAQB-143M3.4; FLJ16302; hNotch4; MGC74442; Neurogenic locus notch homolog protein 4; Notch 4; Notch 4 extracellular truncation; Notch 4 intracellular domain; Notch homolog 4; NOTCH3
Gene Aliases: INT3; NOTCH4
UniProt ID: (Human) Q99466
Entrez Gene ID: (Human) 4855