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Product Details
PA5-40479
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human NOTCH4
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2605872
Product Specific Information
Peptide sequence: KALKPKAEVD EDGVVMCSGP EEGEEVGQAE ETGPPSTCQL WSLSGGCGAL
Sequence homology: Cow: 92%; Dog: 77%; Guinea Pig: 79%; Horse: 92%; Human: 100%; Pig: 100%; Rabbit: 79%
Target Information
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases (entrez gene).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAQB-143M3.4; FLJ16302; hNotch4; MGC74442; Neurogenic locus notch homolog protein 4; Notch 4; Notch homolog 4; NOTCH3
Gene Aliases: INT3; NOTCH4
UniProt ID: (Human) Q99466
Entrez Gene ID: (Human) 4855
patterning of blood vessels
cell fate determination
morphogenesis of a branching structure
endothelial cell morphogenesis
transcription initiation from RNA polymerase II promoter
Notch signaling pathway
Notch receptor processing
positive regulation of transcription of Notch receptor target
embryo development
hemopoiesis
cell differentiation
mammary gland development
negative regulation of cell differentiation
negative regulation of endothelial cell differentiation
positive regulation of transcription, DNA-templated
Performance Guarantee
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