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Product Details
PA5-96995
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1824-2003 of human NOTCH4 (NP_0045483)
Conjugate
Form
Liquid
Concentration
0.85 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808797
Product Specific Information
Immunogen sequence: PPEARHKATP GREAGPFPRA RTVSVSVPPH GGGALPRCRT LSAGAGPRGG GACLQARTWS VDLAARGGGA YSHCRSLSGV GAGGGPTPRG RRFSAGMRGP RPNPAIMRGR YGVAAGRGGR VSTDDWPCDW VALGACGSAS NIPIPPPCLT PSPERGSPQL DCGPPALQEM PINQGGEGKK; Positive Samples: Mouse kidney; Cellular Location: Cell membrane, Nucleus, Single-pass type I membrane protein
Target Information
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases (entrez gene).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAQB-143M3.4; FLJ16302; hNotch4; MGC74442; Neurogenic locus notch homolog protein 4; Notch 4; Notch gene homolog 4; Notch homolog 4; NOTCH3
Gene Aliases: Int-3; INT3; N4; NOTCH4
UniProt ID: (Human) Q99466, (Mouse) P31695
Entrez Gene ID: (Human) 4855, (Rat) 406162, (Mouse) 18132
patterning of blood vessels
cell fate determination
morphogenesis of a branching structure
endothelial cell morphogenesis
transcription initiation from RNA polymerase II promoter
Notch signaling pathway
Notch receptor processing
positive regulation of transcription of Notch receptor target
embryo development
hemopoiesis
cell differentiation
mammary gland development
negative regulation of cell differentiation
negative regulation of endothelial cell differentiation
positive regulation of transcription, DNA-templated
endothelial cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
regulation of Notch signaling pathway
regulation of protein localization
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
regulation of protein processing
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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