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Immunogen sequence: SAILGTEKST DGSKDVVEIA VPENLVGAIL GKGGKTLVEY QELTGARIQI SKKGEFVPGT RNRKVTITGT PAATQAAQYL ITQRITYEQG VRAANPQKVG; Positive Samples: U-251MG, SH-SY5Y; Cellular Location: Nucleus
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.
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Protein Aliases: Neuro-oncological ventral antigen 1; Onconeural ventral antigen 1; Paraneoplastic Ri antigen; RNA-binding protein Nova-1; Ventral neuron-specific protein 1
Gene Aliases: Nova-1; NOVA1
UniProt ID: (Human) P51513
Entrez Gene ID: (Human) 4857
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