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Invitrogen
NOX2 Polyclonal Antibody
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FIGURE: 1 / 2
NOX2 Antibody (PA5-34600) in IHC, ICC/IF
Journal of neurotrauma 2018 -
FIG. 3. Nicotinamide adenine dinucleotide phosphate oxidase (NOX) isoforms show a differential increase in different brain regions. Fluorescence intensities (red) of NOX1 and NOX2 in the hippocampus and cerebellum from control and blast-injury animals. Quantification of fluorescence intensities in different brain regions show a striking increase in NOX1 in the hippocampus of blast-injured animals compared w... View More
Product Details
PA5-34600
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 100 - 200 of Human NOX2/gp91phox.
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
Heat mediated antigen retrieval recommended prior to tissue staining.
Target Information
Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase complex expresses in phagocytes, neuroepithelial bodies, vascular smooth muscle cells, and endothelial cells. It includes a membrane bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet possess distinct expression patterns. gp91-phox expresses in eosinophils, neutrophils, monocytes, and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, with low expression in the uterus and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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