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Proteintech
NOX4 Polyclonal Antibody
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Product Details
14347-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NOX4 Fusion Protein Ag5687 (224-578 aa encoded by BC040105)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PGCISLNRT SSQNISLPEY FSEHFHEPFP EGFSKPAEFT QHKFVKICME EPRFQANFPQ TWLWISGPLC LYCAERLYRY IRSNKPVTII SVISHPSDVM EIRMVKENFK ARPGQYITLH CPSVSALENH PFTLTMCPTE TKATFGVHLK IVGDWTERFR DLLLPPSSQD SEILPFIQSR NYPKLYIDGP FGSPFEESLN YEVSLCVAGG IGVTPFASIL NTLLDDWKPY KLRRLYFIWV CRDIQSFRWF ADLLCMLHNK FWQENRPDYV NIQLYLSQTD GIQKIIGEKY HALNSRLFIG RPRWKLLFDE IAKYNRGKTV GVFCCGPNSL SKTLHKLSNQ NNSYGTRFEY NKESFS (224-578 aa encoded by BC040105)
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX-1; KOX1; NADPH oxidase 4; NOX 4; NOX-4; Renal NAD(P)H-oxidase; Superoxide-generating NADPH oxidase 4
Gene Aliases: AI648021; KOX; KOX-1; NOX4; RENOX
UniProt ID: (Human) Q9NPH5, (Rat) Q924V1, (Mouse) Q9JHI8
Entrez Gene ID: (Human) 50507, (Rat) 85431, (Mouse) 50490
nucleotide binding
protein binding
electron carrier activity
NAD(P)H oxidase activity
superoxide-generating NADPH oxidase activity
oxygen sensor activity
heme binding
flavin adenine dinucleotide binding
modified amino acid binding
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
oxidoreductase activity
oxidase
response to reactive oxygen species
cell morphogenesis
response to hypoxia
superoxide metabolic process
inflammatory response
cell aging
negative regulation of cell proliferation
gene expression
positive regulation of smooth muscle cell migration
superoxide anion generation
positive regulation of apoptotic process
positive regulation of MAP kinase activity
bone resorption
homocysteine metabolic process
positive regulation of stress fiber assembly
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
oxidation-reduction process
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
cellular response to glucose stimulus
cellular response to gamma radiation
cellular response to transforming growth factor beta stimulus
reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
aging
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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