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Invitrogen
NOX4 Polyclonal Antibody
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FIGURE: 1 / 5
NOX4 Antibody (PA5-53304) in WB
Western blot was performed using Anti-NOX4 Polyclonal Antibody (Product # PA5-53304) and a 70kDa band corresponding to NOX4 was observed across in A549 and Mouse Kidney in comparison to NIH: OVCAR-3 which is reported to be negative. Whole cell extracts (30 µg lysate) of A549 (Lane 1), NIH:OVCAR-3 (Lane 2), Mouse Kidney (Lane 3) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Produc... View More
Product Details
PA5-53304
Applications
Tested Dilution
Publications
Product Specifications
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NOX4
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
Immunogen sequence: ISLNRTSSQN ISLPEYFSEH FHEPFPEGFS KPAEFTQHKF VKICMEEPRF QANFPQTWLW ISGPLCLYCA ERLYRYIRSN KPVTIISVIS HPSDVMEIRM VKENFKARPG QYI
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 77%.
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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