The target sequence has 93% sequence homology with human.
Dietary consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, which factor into the risk of coronary heart disease. Niemann-Pick type C1 Like 1 protein (NPC1L1 or NPC3) is enriched in the small intestine and is found in the brush border membrane of enterocytes. It plays a critical role in absorption of intestinal cholesterol.
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Protein Aliases: BC 400-127; Niemann-Pick C1-like protein 1; Niemann-Pick C3; Niemann-Pick disease, type C1; Niemann-Pick disease, type C1-like 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC1 like 1; NPC1-like 1; NPC1-like intracellular cholesterol transporter 1; NPC3
Gene Aliases: 9130221N23Rik; Gm243; NPC11L1; NPC1L1